Light sheet systems that work for scientists

Complete Light Sheet Solutions, By Scientists For Scientists.

The promise of light sheet has been a balance of speed and resolution. Gentle enough for live samples with enough resolution and speed needed to capture dynamic events or provide throughput for vast scales of volumetric data. LiT delivers that promise with the right balance.

The challenge with traditional and existing light sheet microscopes

LBS Provides improved optical sectioning and SNR than traditional SPIM at cellular level. Scale Bars: 3um

Axial profile of gaussian light sheet with similar thickness

Axial profile of LBS

Our vision for lightsheet was driven by scientists grappling with challenges in current systems...

Many light sheet systems have advanced by solving one particular problem well, but too many systems suffer from a range of challenges. Scientists need easy to use systems that maximize total scientific throughput, avoiding a complete mix of problems...

Long acquisition times

Difficulties in alignment

Uneven illumination

Non-uniform images that can't be analyzed

Data too big to efficiently analyze

Complications in sample mounting

Complications in operation

Uneven illumination

Uncertainty about clearing methods

Uncertainty about analysis methods

Solving the total equation...

... with a balanced approach to optical and total workflow efficiency

Introducing

Our LiTone Light-Sheet Microscopes

Our light sheet systems are built to work for scientists. Coupling our patented Line Bessel Sheet (LBS) technology with optical designs fit for a broad range of applications from fast, incubated live cell and tissue imaging to large, cleared samples, we have the right systems to unlock the promise of light sheet in your lab. Learn more about our systems below or contact our knowledgeable staff to learn more about which system is right for you.

LiTone XL

A versatile tool for imaging large cleared tissue with extraordinary resolution

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LiTone LBS

Dedicated to sensitive samples needing the highest resolution and live cell incubation.

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Mouse embryoNerves561nm laser channel4x objective lens NA0.28Imaging time: 15minsData size: 122GB

Whole cleared mouse brainfDisco protocol20x14x8mm4x, 0.28 N.A. lens370 GB, 97 min

LiTone LBS

Versatile systems optimized for your science

We know one size doesn’t fit all, so we created the LiTone XL and LiTone LBS systems. Both use our patented Line Bessel Sheets with optical configurations optimized for total throughput and meaningful data generation. The XL system is optimized for throughput

Fast live sample imaging

Stunning 3D Resolution

Ultra-low phototoxicity

Greatly reduced file size

Highly automated acquisition

Superior evenness of illumination

Ground-Breaking Features

Unique four-side illumination

significantly increases the illumination depth and uniformity especially in large cleared samples.

LBS light-sheets and RI correction optics

for the best performance. Resolution up to 500nm.

Compact bench-top design

with built-in vibration isolation. No air-table is required.

Smart and user-friendly LitScan software

with rapid data processing, built-in 3D rendering, multi-position acquisition, auto-stitching and deconvolution.

Capable of long-term imaging for living embryos.

LiTone XL is designed for cleared tissue imaging but is also a proven platform for imaging live Zebrafish or Drosophilaembryos with much higher through put than conventional light sheetmicroscopes.

Applications

Cleared mouse organs, including heart, liver, pancreas, lung and kidney

Cleared mouse brain, showing blood vessels and tumor sites

Living zebrafish embryo (GFP
motor neuron, 24-36hpf)

Cancer cells (yellow) interacting with human epithelial cells (cyan), captured by LiTone LBS

Lightning fast data analysis

LiTone light sheet microscopes have been widely tested and applied in a vast range of applications in universities, industries and hospitals.

Applicable to a wide range of samples, from bacteria, cells, embryos to cleared tissue

Has been intensively tested by over 50 universities, research institutes, pharmaceutical companies and hospitals world-wide since 2014

We offer immersive user support and customization for tailored discovery

The power to bring your scientific insights to the world is just a few clicks away